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DMSO: Many Uses, Much Controversy
Maya Muir
http://www.dmso.org/articles/information/muir.htm

Abstract

Dimethyl sulfoxide (DMSO), a by-product of the wood industry, has been in use as a commercial solvent since 1953. It is also one of the most studied but least understood pharmaceutical agents of our time--at least in the United States. According to Stanley Jacob, MD, a former head of the organ transplant program at Oregon Health Sciences University in Portland, more than 40,000 articles on its chemistry have appeared in scientific journals, which, in conjunction with thousands of laboratory studies, provide strong evidence of a wide variety of properties. (See Major Properties Attributed to DMSO) Worldwide, some 11,000 articles have been written on its medical and clinical implications, and in 125 countries throughout the world, including Canada, Great Britain, Germany, and Japan, doctors prescribe it for a variety of ailments, including pain, inflammation, scleroderma, interstitial cystitis, and arthritis elevated intercranial pressure.

Yet in the United States, DMSO has Food and Drug Administration (FDA) approval only for use as a preservative of organs for transplant and for interstitial cystitis, a bladder disease. It has fallen out of the limelight and out of the mainstream of medical discourse, leading some to believe that it was discredited. The truth is more complicated.

DMSO: A History of Controversy

The history of DMSO as a pharmaceutical began in 1961, when Dr. Jacob was head of the organ transplant program at Oregon Health Sciences University. It all started when he first picked up a bottle of the colorless liquid. While investigating its potential as a preservative for organs, he quickly discovered that it penetrated the skin quickly and deeply without damaging it. He was intrigued. Thus began his lifelong investigation of the drug.

The news media soon got word of his discovery, and it was not long before reporters, the pharmaceutical industry, and patients with a variety of medical complaints jumped on the news. Because it was available for industrial uses, patients could dose themselves. This early public interest interfered with the ability of Dr. Jacob--or, later, the FDA--to see that experimentation and use were safe and controlled and may have contributed to the souring of the mainstream medical community on it.

Why, if DMSO possesses half the capabilities claimed by Dr. Jacob and others, is it still on the sidelines of medicine in the United States today?

"It's a square peg being pushed into a round hole," says Dr. Jacob. "It doesn't follow the rifle approach of one agent against one disease entity. It's the aspirin of our era. If aspirin were to come along today, it would have the same problem. If someone gave you a little white pill and said take this and your headache will go away, your body temperature will go down, it will help prevent strokes and major heart problems--what would you think?"

Others cite DMSO's principal side effect: an odd odor, akin to that of garlic, that emanates from the mouth shortly after use, even if use is through the skin. Certainly, this odor has made double-blinded studies difficult. Such studies are based on the premise that no one, neither doctor nor patient, knows which patient receives the drug and which the placebo, but this drug announces its presence within minutes.

Others, such as Terry Bristol, a Ph.D. candidate from the University of London and president of the Institute for Science, Engineering and Public Policy in Portland, Oregon, who assisted Dr. Jacob with his research in the 1960s and 1970s, believe that the smell of DMSO may also have put off the drug companies, that feared it would be hard to market. Worse, however, for the pharmaceutical companies was the fact that no company could acquire an exclusive patent for DMSO, a major consideration when the clinical testing required to win FDA approval for a drug routinely runs into millions of dollars. In addition, says Mr. Bristol, DMSO, with its wide range of attributes, would compete with many drugs these companies already have on the market or in development.

The FDA and DMSO

In the first flush of enthusiasm over the drug, six pharmaceutical companies embarked on clinical studies. Then, in November 1965, a woman in Ireland died of an allergic reaction after taking DMSO and several other drugs. Although the precise cause of the woman's death was never determined, the press reported it to be DMSO. Two months later, the FDA closed down clinical trials in the United States, citing the woman's death and changes in the lenses of certain laboratory animals that had been given doses of the drug many times higher than would be given humans.

Some 20 years and hundreds of laboratory and human studies later, no other deaths have been reported, nor have changes in the eyes of humans been documented or claimed. Since then, however, the FDA has refused seven applications to conduct clinical studies, and approved only 1, for intersititial cystitis, which subsequently was approved for prescriptive use in 1978.

Dr. Jacob believes the FDA "blackballed" DMSO, actively trying to kill interest in a drug that could end much suffering. Jack de la Torre, MD, Ph.D., professor of neurosurgery and physiology at the University of New Mexico Medical School in Albuquerque, a pioneer in the use of DMSO and closed head injury, says, "Years ago the FDA had a sort of chip on its shoulder because it thought DMSO was some kind of snake oil medicine. There were people there who were openly biased against the compound even though they knew very little about it. With the new administration at that agency, it has changed a bit." The FDA recently granted permission to conduct clinical trials in Dr. de la Torre's field of closed head injury.

DMSO Penetrates Membranes and Eases Pain

The first quality that struck Dr. Jacob about the drug was its ability to pass through membranes, an ability that has been verified by numerous subsequent researchers.1 DMSO's ability to do this varies proportionally with its strength--up to a 90 percent solution. From 70 percent to 90 percent has been found to be the most effective strength across the skin, and, oddly, performance drops with concentrations higher than 90 percent. Lower concentrations are sufficient to cross other membranes. Thus, 15 percent DMSO will easily penetrate the bladder.2

In addition, DMSO can carry other drugs with it across membranes. It is more successful ferrying some drugs, such as morphine sulfate, penicillin, steroids, and cortisone, than others, such as insulin. What it will carry depends on the molecular weight, shape, and electrochemistry of the molecules. This property would enable DMSO to act as a new drug delivery system that would lower the risk of infection occurring whenever skin is penetrated.

DMSO perhaps has been used most widely as a topical analgesic, in a 70 percent DMSO, 30 percent water solution. Laboratory studies suggest that DMSO cuts pain by blocking peripheral nerve C fibers.3 Several clinical trials have demonstrated its effectiveness,4,5 although in one trial, no benefit was found.6 Burns, cuts, and sprains have been treated with DMSO. Relief is reported to be almost immediate, lasting up to 6 hours. A number of sports teams and Olympic athletes have used DMSO, although some have since moved on to other treatment modalities. When administration ceases, so do the effects of the drug.

Dr. Jacob said at a hearing of the U.S. Senate Subcommittee on Health in 1980, "DMSO is one of the few agents in which effectiveness can be demonstrated before the eyes of the observers....If we have patients appear before the Committee with edematous sprained ankles, the application of DMSO would be followed by objective diminution of swelling within an hour. No other therapeutic modality will do this."

Chronic pain patients often have to apply the substance for 6 weeks before a change occurs, but many report relief to a degree they had not been able to obtain from any other source.

DMSO and Inflammation

DMSO reduces inflammation by several mechanisms. It is an antioxidant, a scavenger of the free radicals that gather at the site of injury. This capability has been observed in experiments with laboratory animals7 and in 150 ulcerative colitis patients in a double-blinded randomized study in Baghdad, Iraq.8 DMSO also stabilizes membranes and slows or stops leakage from injured cells.

At the Cleveland Clinic Foundation in Cleveland, Ohio, in 1978, 213 patients with inflammatory genitourinary disorders were studied. Researchers concluded that DMSO brought significant relief to the majority of patients. They recommended the drug for all inflammatory conditions not caused by infection or tumor in which symptoms were severe or patients failed to respond to conventional therapy.9

Stephen Edelson, MD, F.A.A.F.P., F.A.A.E.M., who practices medicine at the Environmental and Preventive Health Center of Atlanta, has used DMSO extensively for 4 years. "We use it intravenously as well as locally," he says. "We use it for all sorts of inflammatory conditions, from people with rheumatoid arthritis to people with chronic low back inflammatory-type symptoms, silicon immune toxicity syndromes, any kind of autoimmune process.

"DMSO is not a cure," he continues. "It is a symptomatic approach used while you try to figure out why the individual has the process going on. When patients come in with rheumatoid arthritis, we put them on IV DMSO, maybe three times a week, while we are evaluating the causes of the disease, and it is amazing how free they get. It really is a dramatic treatment."

As for side effects, Dr. Edelson says: "Occasionally, a patient will develop a headache from it, when used intravenously--and it is dose related." He continues: "If you give a large dose, [the patient] will get a headache. And we use large doses. I have used as much as 30ÝmlÝIV over a couple of hours. The odor is a problem. Some men have to move out of the room [shared] with their wives and into separate bedrooms. That is basically the only problem."

DMSO was the first nonsteroidal anti-inflammatory discovered since aspirin. Mr. Bristol believes that it was that discovery that spurred pharmaceutical companies on to the development on other varieties of nonsteroidal anti-inflammatories. "Pharmaceutical companies were saying that if DMSO can do this, so can other compounds," says Mr. Bristol. "The shame is that DMSO is less toxic and has less int he way of side effects than any of them."

Collagen and Scleroderma

Scleroderma is a rare, disabling, and sometimes fatal disease, resulting form an abnormal buildup of collagen in the body. The body swells, the skin--particularly on hands and face--becomes dense and leathery, and calcium deposits in joints cause difficulty of movement. Fatigue and difficulty in breathing may ensue. Amputation of affected digits may be necessary. The cause of scleroderma is unknown, and, until DMSO arrived, there was no known effective treatment.

Arthur Scherbel, MD, of the department of rheumatic diseases and pathology at the Cleveland Clinic Foundation, conducted a study using DMSO with 42 scleroderma patients who had already exhausted all other possible therapies without relief. Dr. Scherbel and his coworkers concluded 26 of the 42 showed good or excellent improvement. Histotoxic changes were observed together with healing of ischemic ulcers on fingertips, relief from pain and stiffness, and an increase in strength. The investigators noted, "It should be emphasized that these have never been observed with any other mode of therapy."10 Researchers in other studies have since come to similar conclusions.11

Does DMSO Help Arthritis?

It was inevitable that DMSO, with its pain-relieving, collagen-softening, and anti-inflammatory characteristics, would be employed against arthritis, and its use has been linked to arthritis as much as to any condition. Yet the FDA has never given approval for this indication and has, in fact, turned down three Investigational New Drug (IND) applications to conduct extensive clinical trials.

Moreover, its use for arthritis remains controversial. Robert Bennett, MD, F.R.C.P., F.A.C.R., F.A.C.P., professor of medicine and chief, division of arthritis and rheumatic disease at Oregon Health Sciences University (Dr. Jacob's university), says other drugs work better. Dava Sobel and Arthur Klein conducted their own informal study of 47 arthritis patients using DMSO in preparation for writing their book, Arthritis: What Works, and came to the same conclusion.12

Yet laboratory studies have indicated that DMSO's capacity as a free-radical scavenger suggests an important role for it in arthritis.13 The Committee of Clinical Drug Trials of the Japanese Rheumatism Association conducted a trial with 318 patients at several clinics using 90 percent DMSO and concluded that DMSO relieved joint pain and increased range of joint motion and grip strength, although performing better in more recent cases of the disease.14 It is employed widely in the former Soviet Union for all the different types of arthritis, as it is in other countries around the world.

Dr. Jacob remains convinced that it can play a significant role in the treatment of arthritis. "You talk to veterinarians associated with any race track, and you'll find there's hardly an animal there that hasn't been treated with DMSO. No veterinarian is going to give his patient something that does not work. There's no placebo effect on a horse."

DMSO and Central Nervous System Trauma

Since 1971, Dr. de la Torre, then at the University of Chicago, has experimented using DMSO with injury to the central nervous system. Working with laboratory animals, he discovered that DMSO lowered intracranial pressure faster and more effectively than any other drug. DMSO also stabilized blood pressure, improved respiration, and increased urine output by five times and increased blood flow through the spinal cord to areas of injury.15-17 Since then, DMSO has been employed with human patients suffering severe head trauma, initially those whose intracranial pressure remained high despite the administration of mannitol, steroids, and barbiturates. In humans, as well as animals, it has proven the first drug to significantly lower intracranial pressure, the number one problem with severe head trauma.

"We believe that DMSO may be a very good product for stroke," says Dr. de la Torre, "and that is a devastating illness which affects many more people than head injury. We have done some preliminary clinical trials, and there's a lot of animal data showing that it is a very good agent in dissolving clots."

Other Possible Applications for DMSO

Many other uses for DMSO have been hypothesized from its known qualities hand have been tested in the laboratory or in small clinical trials. Mr. Bristol speaks with frustration about important findings that have never been followed up on because of the difficulty in finding funding and because "to have on your resume these days that you've worked on DMSO is the kiss of death." It is simply too controversial. A sampling of some other possible applications for this drug follows.

DMSO as long been used to promote healing. People who have it on hand often use it for minor cuts and burns and report that recovery is speedy. Several studies have documented DMSO use with soft tissue damage, local tissue death, skin ulcers, and burns.18-21

In relation to cancer, several properties of DMSO have gained attention. In one study with rats, DMSO was found to delay the spread of one cancer and prolong survival rates with another.22 In other studies, it has been found to protect noncancer cells while potentiating the chemotherapeutic agent.

Much has been written recently about the worldwide crisis in antibiotic resistance among bacteria (see Alternative & Complementary Therapies, Volume 2, Number 3, 1996, pages 140-144) Here, too, DMSO may be able to play a role. Researcher as early as 1975 discovered that it could break down the resistance certain bacteria have developed.23

In addition to its ability to lower intracranial pressure following closed head injury, Dr. de la Torre's work suggests that the drug may actually have the ability to prevent paralysis, given its ability to speedily clean out cellular debris and stop the inflammation that prevents blood from reaching muscle, leading to the death of muscle tissue.

With its great antioxidant powers, DMSO could be used to mitigate some of the effects of aging, but little work has been done to investigate this possibility. Toxic shock, radiation sickness, and septicemia have all been postulated as responsive to DMSO, as have other conditions too numerous to mention here.

DMSO in the Future

Will DMSO ever sit on the shelves of pharmacies in this country as a legal prescriptive for many of the conditions it may be able to address? Will the studies we need to discover when this drug is most appropriate ever be done? Given the difficulties the drug has run into so far and the recent development of new drugs that perform some of the same functions, Mr. Bristol is doubtful. Others, however, such as Dr. Jacob and Dr. de la Torre, see the FDA approval of DMSO for interstitial cystitis and the more recent FDA go-ahead for DMSO trials with closed head injury as new indications of hope. The cystitis approval means that physicians may use it at their discretion for other uses, giving DMSO a new legitimacy.

Dr. Jacob continues to believe that DMSO should not even be called a drug but is more correctly a new therapeutic principle, with an effect on medicine that will be profound in many areas. Whether that is true cannot be known without extensive a publicly reported trials, which are dependent on the willingness of researchers to undertake rigorous studies in this still-unfashionable tack and of pharmaceutical companies and other investors to back them up. That this is a live issue is proved by the difficulty the investigators with approval to test DMSO for closed head injury clinically are having finding funds to conduct the trials.

In 1980, testifying before the Select Committee on Agin of the U.S. House of Representatives, Dr. Scherbel said, "The controversy that exists over the clinical effectiveness of DMSO is not well-founded--clinical effectiveness may be variable in different patients. If toxicity is consistently minimal, the drug should not be restricted from practice. The clinical effectiveness of DMSO can be decided with complete satisfaction if the drug is made available to the practicing physician. The number of patient complaints about pain and the number of phone calls to the doctor's office will decide quickly whether or not the drug is effective."

It may be premature to call for the full rehabilitation of DMSO, but it is time to call for a full investigation of its true range of capabilities.

References

  1. Kolb, K.H., Jaenicke, G., Kramer, M., Schulze, P.E. Absorption, distribution, and elimination of labeled dimethyl sulfoxide in man and animals. Ann NY Acad Sci 141:85-95, 1967.
  2. Herschler, R., Jacob, S.W. The case of dimethyl sulfoxide. In: Lasagna, L. (Ed.), Controversies in Therapeutics. Philadelphia: W.B. Saunders, 1980.
  3. Evans, M.S., Reid, K.H., Sharp, J.B. Dimethyl sulfoxide (DMSO) blocks conduction in peripheral nerve C fibers: A possible mechanism of analgesia. Neurosci Lett 150:145-148, 1993.
  4. Demos, C.H., Beckloff, G.L., Donin, M.N., Oliver, P.M. Dimethyl sulfoxide in musculoskeletal disorders. Ann NY Acad Sci 141:517-523, 1967.
  5. Lockie, L.M., Norcross, B. A clinical study on the effects of dimethyl sulfoxide in 103 patients with acute and chronic musculoskeletal injures and inflammation. Ann NY Acad Sci 141:599-602, 1967.
  6. Percy, E.C., Carson, J.D. The use of DMSO in tennis elbow and rotator cuff tendinitis: A double-blind study. Med Sci Sports Exercise 13:215-219, 1981.
  7. Itoh, M., Guth, P. Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology 88:1126-1167, 1985.
  8. Salim, A.S., Role of oxygen-derived free radical scavengers in the management of recurrent attacks of ulcerative colitis: A new approach. J. Lab Clin Med 119:740-747, 1992.
  9. Shirley, S.W., Stewart, B.H., Mirelman, S. Dimethyl sulfoxide in treatment of inflammatory genitourinary disorders. Urology 11:215-220, 1978.
  10. Scherbel, A.L., McCormack, L.J., Layle, J.K. Further observations on the effect of dimethyl sulfoxide in patients with generalized scleroderma (progressive systemic sclerosis). Ann NY Acad Sci 141:613-629, 1967.
  11. Engel, M.F., Dimethyl sulfoxide in the treatment of scleroderma. South Med J 65:71, 1972.
  12. Sobel, D., Klein, A.C. Arthritis: What Works. New York: St. Martins Press, 1989.
  13. Santos, L., Tipping, P.G. Attenuation of adjuvant arthritis in rats by treatment with oxygen radical scavengers. Immunol Cell Biol 72:406-414, 1994.
  14. Matsumoto, J. Clinical trials of dimethyl sulfoxide in rheumatoid arthritis patients in Japan. Ann NY Acad Sci 141:560-568, 1967.
  15. de la Torre, J.C., et al. Modifications of experimental spinal cord injuries using dimethyl sulfoxide. Trans Am Neurol Assoc 97:230, 1971.
  16. de la Torre, J.C., et al. Dimethyl sulfoxide in the treatment of experimental brain compression. J Neurosurg 38:343, 1972.
  17. de la Torre, J.C., et al. Dimethyl sulfoxide in the central nervous system trauma. Ann NY Acad Sci 243:362, 1975.
  18. Lawrence, H.H., Goodnight, S.H. Dimethyl sulfoxide and extravasion of anthracycline agents. Ann Inter Med 98:1025, 1983.
  19. Lubredo, L., Barrie, M.S., Woltering, E.A. DMSO protects against adriamycin-induced skin necrosis. J. Surg Res 53:62-65, 1992.
  20. Alberts, D.S., Dorr, R.T. Case report: Topical DMSO for mitomycin-C-induced skin ulceration. Oncol Nurs Forum 18:693-695, 1991.
  21. Cruse, C.W., Daniels, S. Minor burns: Treatment using a new drug deliver system with silver sulfadiazine. South Med J 82:1135-1137, 1989.
  22. Miller, L., Hansbrough, J., Slater, H., et al. Sildimac: A new deliver system for silver sulfadiazine in the treatment of full-thickness burn injuries. J Burn Care Rehab 11:35-41, 1990
  23. Salim, A. Removing oxygen-derived free radicals delays hepatic metastases and prolongs survival in colonic cancer. Oncology 49:58-62, 1992.
  24. Feldman, W.E., Punch, J.D., Holden, P. In vivo and in vitro effects of dimethyl sulfoxide on streptomycin-sensitive and resistant Escherichia coli. Ann Acad Sci 141:231, 1967.

Source: Alternative & Complementary Therapies, July/August 1996, pages 230-235. DMSO Organization would like to thank the publisher for permission to place this fine article on the World Wide Web. The Publisher retains all copyright. To order reprints of this article, write to or call: Karen Ballen, Alternative & Complementary Therapies, Mary Ann Liebert, Inc., 2 Madison Avenue, Larchmont, NY 10538, (914) 834-3100.

 

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The Magic Duo for Cancer Treatment That Frightens The FDA and Conventional Medicine

August 22, 2013 | By | 8 Replies

Dave Mihalovic, Prevent Disease
Waking Times

Use of DMSO (Dimethyl sulfoxide) in medicine dates back decades. It was predominantly used as a topical anagesic, anti-inflammatory and antioxidant. Today, we know that DMSO can treat a variety of disorders including arthritis, mental illness, emphysema, and even cancerWhile this is now considered a superb cancer treatment, orthodox medicine is not interested in discussing its benefits. If DMSO were to be implemented and used in cancer treatment, the “true cure rate” for orthodox medicine would rise from 3% to above 90%! Here’s why.

Supporters of DMSO have long supported the claim that it can cause cancerous cells to become noncancerous, or benign, and can slow or stop the progress of cancer in the bladder, colon, ovary, breast, and skin. Some evidence even suggest it is useful in treating leukemia, and it has also been used as a part of some metabolic cancer therapies.

DMSO was first discovered in the mid- to late nineteenth century. In the 1950s, it was discovered that DMSO could protect cells from the damage of freezing. In the 1960s, Dr. Stanley Jacob, one of the main proponents of DMSO, began to study other medicinal properties of the substance. In the 1970s, DMSO was approved for use as an anti-inflammatory treatment in dogs and horses and as a prescription drug for a type of bladder inflammation in humans.

If orthodox medicine were truly interested in curing cancer, don’t you think they would look for a way to target cancer cells with the intent of killing them while sparing normal cells?

Chemotherapy does not target cancer cells, and because of this, chemotherapy:
1) Kills far more normal cells than cancer cells, and
2) Damages and toxifies many of the normal cells that do survive.

If a “magic bullet” were used FIRST by orthodox medicine, meaning thecut/burn/slash/poison treatments were avoided, a 90% true cure rate would be easy to achieve. But the fact of the matter is that the leaders in the medical community have absolutely no interest in finding a “magic bullet.” A “magic bullet” would cost the drug companies hundreds of billions of dollars, patients would have less hospitalization, less doctor visits, etc. The fact is, no one wants a “magic bullet” to be found. The evidence that this is true is that two “magic bullets” are already known to exist, but no one is using them except for a handful of doctors.

What Causes Cancer?

Most people believe that it is DNA damage that causes cancer. While in rare situations, DNA can have a negative affect on a person’s immune system, DNA normally has absolutely nothing to do with the development of cancer.

The fact is that cancer is caused by a special type of microbe which gets inside of normal cells and turns the cells cancerous.

Cancer is an invading disease that attacks the body’s immune system. Once detected, cancer has already had enough time to establish its web network. Treating the tumor is not good enough–it is only the start.

Actually, everyone has cancer cells forming in their body at all times. The immune system generally safely kills them. However, this means that a weakened immune system, and many other things, can allow cancer cells to overcome the immune system. But the actual formation of cancer cells is exclusively caused by microbes which get inside of normal cells.

Dr. Royal Rife did an enormous amount of research into the relationship between microbes and cancer in the 1930s. He would inject mice with a virus and in 100% of the cases the mice would get cancer.

Dr. Rife proposed a cure for cancer which did nothing but kill the viruses/microbes which were inside of the cancer cells. His cure was 100% successful. However, note that his cure had no intention of killing cancer cells or fixing DNA (which had not been discovered in the 1930s); its only goal was to kill microbes which were both inside and outside of the cancer cells. Once the microbes were dead the cancer cells were able to revert back into normal, differentiated cells.

Dr. Rife was well aware that the critial microbes which needed to be killed were inside the cancer cells. The electromedicine device he used killed microbes inside and outside of cancer cells.

But almost all natural substances do not normally get inside of cells, thus it is almost impossible for natural substances to kill the microbes inside the cancer cells. Natural substances can kill cancer cells and build the immune system, but they generally cannot kill microbes inside the cancer cells.

There is no single cure for treating cancer; cancer must be approached and treated holistically. The cellular process in developing cancer takes many years–with the exception of high radiation or other toxic exposure, a compromised immunity and cell damage does not happen overnight. Treatment must be approached defensively and directly; focus on the cause and do not treat cancer in reverse. Target your treatment mentally and physically from the very origin.

DMSO

You might ask your oncologist why your chances of survival are only 3% (ignoring all of their statistical gibberish such as “5-year survival rates” and deceptive terms like “remission” and “response”), when your chance of survival would be over 90% if they used DMSO.

It would be better for medical doctors to treat cancer patients with the right treatment than to have patients treat themselves at home. Medical doctors can diagnose better, treat better, watch for developing problems better, etc. Unfortunately, doctors are using treatments that have been chosen solely on the basis of their profitability rather than their effectiveness.

DMSO is a highly non-toxic, 100% natural product that comes from the wood industry. But of course, like so many other potential cancer cures, the discovery was buried. DMSO, being a natural product, cannot be patented and cannot be made profitable because it is produced by the tonin the wood industry. The only side-effect of using DMSO in humans is body odor (which varies from patient to patient).

The FDA took note of the effectiveness of DMSO at treating pain and made it illegal for medical uses in order to protect the profits of the aspirin companies (in those days aspirin was used to treat arthritis). Thus, it must be sold today as a “solvent.” Few people can grasp the concept that government agencies are organized for the sole purpose of being the “police force” of large, corrupt corporations.

While it is generally believed that orthodox medicine and modern corrupt politicians persecute alternative medicine, this is not technically correct. What they do is persecute ANY cure for cancer, it doesn’t matter whether it is orthodox or alternative. The proof of this is DMSO. It appears that orthodox medicine persecutes alternative medicine only because there are far more alternative cancer treatments that can cure cancer than orthodox treatments.

Another substance that targets cancer cells is being researched at Purdue University and other places: folic acid. This too will be buried unless it can lead to more profitable cancer treatments.

But alternative medicine is rightfully not interested in combining DMSO with chemotherapy. DMSO will combine with many substances, grab them, and drag them into cancer cells. It will also blast through the blood-brain barrier like it wasn’t even there.

DMSO has been combined successfully with hydrogen peroxide (e.g. see Donsbach), cesium chloride, MSM (though it may not bind to MSM), and other products.

DMSO – Vitamin C Treatment

Vitamin C is so simlar to glucose, that cells, and especially cancer cells, consume vitamin C the same way they would consume glucose.

Cancer cells are anaerobic obligates, which means they depend upon glucose as their primary source of metabolic fuel. Cancer cells employ transport mechanisms called glucose transporters to actively pull in glucose.

In the vast majority of animals, vitamin C is synthesized from glucose in only four metabolic steps. Hence, the molecular shape of vitamin C is remarkably similar to glucose. Cancer cells will actively transport vitamin C into themselves, possibly because they mistake it for glucose. Another plausible explanation is that they are using the vitamin C as an antioxidant. Regardless, the vitamin C accumulates in cancer cells.

If large amounts of vitamin C are presented to cancer cells, large amounts will be absorbed. In these unusually large concentrations, the antioxidant vitamin C will start behaving as a pro-oxidant as it interacts with intracellular copper and iron. This chemical interaction produces small amounts of hydrogen peroxide.

Because cancer cells are relatively low in an intracellular anti-oxidant enzyme called catalase, the high dose vitamin C induction of peroxide will continue to build up until it eventually lyses the cancer cell from the inside out! This effectively makes high dose IVC a non-toxic chemotherapeutic agent that can be given in conjunction with conventional cancer treatments. Based on the work of several vitamin C pioneers before him, Dr. Riordan was able to prove that vitamin C was selectively toxic to cancer cells if given intravenously. This research was recently reproduced and published by Dr. Mark Levine at the National Institutes of Health.

As feared by many oncologists, small doses may actually help the cancer cells because small amounts of vitamin C may help the cancer cells arm themselves against the free-radical induced damage caused by chemotherapy and radiation. Only markedly higher doses of vitamin C willselectively build up as peroxide in the cancer cells to the point of acting in a manner similar to chemotherapy. These tumor-toxic dosages can only be obtained by intravenous administration.

Over a span of 15 years of vitamin C research, Dr. Riordan’s RECNAC (cancer spelled backwards) research team generated 20 published papers on vitamin C and cancer. RECNAC even inspired its second cancer research institute, known as RECNAC II, at the University of Puerto Rico. This group recently published an excellent paper in Integrative Cancer Therapies, titled “Orthomolecular Oncology Review: Ascorbic Acid and Cancer 25 Years Later.” RECNAC data has shown that vitamin C is toxic to tumor cells without sacrificing the performance of chemotherapy.

Intravenous vitamin C also does more than just kill cancer cells. It boosts immunity. It can stimulate collagen formation to help the body wall off the tumor. It inhibits hyaluronidase, an enzyme that tumors use to metastasize and invade other organs throughout the body. It induces apoptosis to help program cancer cells into dying early. It corrects the almost universal scurvy in cancer patients. Cancer patients are tired, listless, bruise easily, and have a poor appetite. They don’t sleep well and have a low threshold for pain. This adds up to a very classic picture of scurvy that generally goes unrecognized by their conventional physicians.

Because cancer cells consume 15 times more glucose than normal cells, under the right conditions, cancer cells should consume 15 times more vitamin C than a normal cell. While normal cells benefit from vitamin C, the microbes inside of the cancer cells may be killed by vitamin C. It is microbes which are inside of the cancer cells which cause cancer and which force a cancer cell to remain cancerous.

It should be mentioned that two-time Nobel Prize winner Linus Pauling, and an associate, Dr. Ewan Cameron, M.D., were able to extend the lives of cancer patients more than 10-fold using only 10 grams of vitamin C a day by I.V.


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Chelerythrine. Chelerythrine is a benzophenanthridine alkaloid extracted from the plant Greater celandine (Chelidonium majus) and from Blood Root (Sanguinaria canadensis). It is a potent, selective, and cell-permeable protein kinase C inhibitor (may improve mood and benefit the heart, is used in several anti-cancer drugs).

What is Nigella Sativa? (Jintan Hitam). Black seed is used for treating gastrointestinal conditions including gas, colic, diarrhea, dysentery, constipation and haemorrhoids. It is also used for respiratory conditions, including asthma, allergies, cough, bronchitis, emphysema, flu and congestion. Additionally, it is used as an antihypertensive, immunoprotectant, anticancer agent, and vermifuge.

About BSI Mangiferin. The colorful history of Mangiferin dates more than 1000 years, a mainstay of Chinese medicine, Balean medicine in Indonesia, and ethno-medicine in Cuba.

Keladi tikus / Typhonium flagelliforme (Lodd.) Bl. The type of cancer that can be inhibited by rodent tuber is in addition to breast cancer nasopharyngeal cancer, liver, cancer of the cervix, pancreas, prostate, lung and many more. In addition to cancer, according to some studies also mentioned that taro rats can be used for people who have drug addiction.

Noni Fruit and Juice and its Benefits. Noni mimics the secretion coming from the pineal gland, and in fact acts as a precursor to it, building it up and allowing it to function fully. It is a noted analgesic or pain reliever.

California Poppy. The California poppy contains protopine, which has similar (but much milder effects) as morphine, making it a good natural sedative.

Research: Pineapple Bromelain Enzyme Kills Cancer Without Killing You. How then, can something as innocuous as the enzyme from the stem/core of a pineapple be superior to a drug that millions of cancers patients over the past 40 years have placed their hopes of recovery on, as well as exchanging billions of dollars for?

Health Benefits of Aloe Vera. Not only does it contain vitamin B12 but several other minerals that are important for the health of our bodies. Aloe vera also contains calcium, protein, zinc, magnesium, vitamins A, and E, germanium, essential fatty acids and amino acids.

The Magic Duo for Cancer Treatment That Frightens The FDA and Conventional Medicine: DMSO.Dimethyl sulfoxide (DMSO), a by-product of the wood industry, has been in use as a commercial solvent since 1953. DMSO can carry other drugs with it across membranes. It is more successful ferrying some drugs, such as morphine sulfate, penicillin, steroids, and cortisone, than others, such as insulin. What it will carry depends on the molecular weight, shape, and electrochemistry of the molecules. This property would enable DMSO to act as a new drug delivery system that would lower the risk of infection occurring whenever skin is penetrated.

6 Benefits of Papaya Leaves to the Human Body One supplement you should not overlook is Papaya Leaf Extract. Papayas are excellent sources of dietary fiber, vitamin C, vitamin A, vitamin E, and folate, while at the same time being rich in antioxidants, flavonoids, and carotenes. Papayas also contain high amounts of enzymes called papain and chymopapain, which are critical ingredients for a healthy body.

Health Benefits of Pine Essential Oil. The health benefits of pine essential oil include its ability to reduce inflammation and associated redness, protect against sinus infections, clear mucus and phlegm, cure skin conditions like eczema and psoriasis, boost the immune system, fight fungal and viral infections, stimulate the mind and body, and protecting your home and body from a wide variety of germs.

Gelatin Capsules Sizes and shapes of Gelatin Capsules.

All About Zinc. Zinc is an essential element, necessary for sustaining all life. It is estimated that 3000 of the hundreds of thousands of proteins in the human body contain zinc. Signs of zinc deficiency includes hair loss, skin lesions, diarrhea, wasting of body tissues. Prolonged lack of zinc can result in death.

Master Index of Health-Related Articles on BSI.International



It's not just about killing cancer....

But also about ending the causes of cancer
so it is no longer needed by the body.
The body expels disease when properly nourished.



Alternative web sites often are lost, are made illegal in the current political climate.

Because of the intrinsic value of this information for the reader, we at BSI, in addition to providing a link to the reference, also reprint it here for safe keeping. We kindly invite the author to contact us.

It appears obvious in many cancer-related publications, the author may be leery of liability. As such one must often read-between-the-lines, to understand what is revealed there. 

"Everything is backwards; everything is upside down. Doctors destroy health, lawyers destroy justice, universities destroy knowledge, governments destroy freedom, and the major media destroy information." ~ Michael Ellner

"Anti-dandruf shampoos cause dandruf and scalp disorders. Weight loss foods and drugs cause weight gain. Prescription drugs cause disease. Health insurance destroys health. Television and advertising kill individuality and inspiration." ~ I Wayan Nyepih

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Our most basic package
(does not include medicines or treatment):
Basic blood / urine and physical exam
for cancer and related diseases
Rp. 1.850.000 Package Price

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A few of the 60+ natural medicines we manufacture at BSI....

Traditional Bloodroot Salve
Compound A
Blood Root Jahe Yellow Powder
Compound B
Blood Root Jahe Magnesium
Yellow Salve

Compound BVC
Goldenseal Comfrey Aloe
Healing Salve

Compound C
Blood Root Jahe Salve
Compound D
Bromelain Papain Powder
Compound G
Jintan Hitam Beet Powder
Compound J
Cancer Killer
Compound K
Manggis Sirsap Powder
Compound L
Colloidal Minerals
Compound M
Noni Mint Powder
Compound NP
Poison Control
Compound S
Digestive Toner and Cleanse
Compound VL
Lung and Sinus Steamer Solution
Compound B Tincture
DMSO Vit C Bloodroot Bicarbonate Magnesium Iodine Jahe
Compound 1-5
Bone & Ligament Rebuilder
Compound O
Oral Parasite Medicine
Compound W
Lung & Sinus Tonic
Compound TL
Zingiberaceae
Jamu BSI

Compound Z

Zingiberaceae
Infusion Enhancement

Compound IZ
Nigella Sativa
Infusion Enhancement

Compound IN
Healing Eye Drops
Vitamin C - Silver - Magnesium - Electrolyte Healing for eyes

Compound ED
Tumor Direct Injection
Compound A-20
Vitamin C and Electrolytes Infusion
Compound IAA
Silver Hydrosol
Infusion Enhancement and Tumor Injection

Compound IS
BodyPure©
Lemon Bath and Body Oil
Compound SO
BodyPure©
Vita Bath
Healing Bath Salts

Compound V
BodyPure©
Trace Elements Body Detox and Skin Purifier
VitaBody
BodyPure©
Natural Insect Repellant
Bug Juice
BodyPure©
Oral Healing Oils
Compound SOS
BodyPure©
Trace Elements Face & Scalp Healing Conditioner
VitaHead
BodyPure©
Oral Healing Kit
Oral Kit
BodyPure©
Body Detox
and Healing Kit

Body Kit

Sorry, the medicines we make are sold only to our patients.