Yes, there are many traditional medicines which has the ability to exceed of
chemotherapy, radiation, drugs and even surgery. One of them is the soursop
leaves, why soursop
leaves for cancer?
Until now, cancer is a scourge for people all over the world. And various
studies have been conducted to find the best cancer drugs.
You might know, how many cancer patients which suffer because of side effects
of chemotherapy. But do you know how smart soursop leaf to handle the cancer
cells?. Let’s discuss together the ability of soursop leaf for handle the
cancer cells, crippling and kill it. That’s why I say to you, soursop
leaves for cancer.
first reason, why soursop leaves for cancer?, these is a herbal medicine
Soursop leaf is one of the traditional ingredients, and we know if the herbal
remedies has advantages over chemical drugs. Because the soursop leaves is
nothing like chemotherapy which has many side effects.
However, based on facts that occurred, you will easily have heat in the body
and shortness of breath. All this is a process performed soursop leaves in
destroying cancer cells. So you don’t have to worry about this.
The second reason, why soursop leaves for cancer?, these is the best
There are many herbal medicine for cancer such as soursop leaves for cancer,
noni juice for cancer, rodent tuber for cancer and another herbal medicine. Are
you know?, if the herbal medicines have a different ways of destroying cancer
cells. So if you combine them, they will become weapons very effective for
curing cancer compared to chemotherapy.
These is the best way for killing
cancer cell naturally.
The third reason, why soursop leaves for cancer?, readily available
and very cheap
Where can you find the chemotherapy, radiation, drugs and even surgery?. You
will only find it in big hospitals and special hospital of cancer. How if you
live in the village?
Then, are you already preparing insurance?, Or a huge cost for such
Compare it, if you are looking for some soursop
leaves for cancer?
All of that is a comparison for you, soursop leaves so easily obtained and so
low cost which you spend to cure
The fourth reason, why soursop leaves for cancer?, very easy to be
It is easy for processing soursop leaves. Provide 10-15 soursop leaves with
aging medium and 3 cups of water. Boil until boiling and the remaining 2 cups,
after that filtered. Boil again soursop leaves with 2 cups of water until
remaining 1 cup. Combine the first boiling water and the second results. So it
will get 3 cups of boiling water soursop leaves. Drink 3 times a day.
Very easy to make water soursop leaf decoction for cancer.
The fifth reason, why soursop leaves for cancer?, there are many
products processed leaves of soursop
You should not hesitate for consume boiling water of soursop leaves.
Everything was easy, if you feel the water boiled of soursop leaves are tasty,
you can try it in a tea or capsule. Currently of soursop leaves are known to the
world, so you don’t need to hesitate about the benefits.
The sixth reason, why soursop leaves for cancer?, soursop leaves are
smarter than chemotherapy
Substances contained in the leaves of soursop (acetogenins) are better able
to differentiate between cancer cells and healthy cells, different from
chemotherapy. It’s only distinguishes cells that perform fast fission, so if
there is healthy cells which perform fission quickly, then it will be detected
as bad cells by chemotherapy medication. And all of these different from the
acetogenins, It was able to distinguish abnormal cells with normal cells.
So that, soursop leaves for cancer is one of the best choice for cancer
How to process the soursop leaves for cancer
There are two ways you can use to obtain benefits soursop leaves for cancer,
directly boiled or dry it first. But this time I will only discuss how to boil
- 10 – 15 soursop leaves, with a half old
- A containers made ??of earthenware (pottery)
- 3 cups of water + 2 cups water
How to process
- Boil the soursop leaves in a first water (3 cups) until the remaining 2
cups, and strain the cooking water
- The soursop leaves are boiled again use 2 cups of water until the
remaining 1 cup, and filtered
- Mix the both of cooking water
- Drink 3 times a day, each 1 cup
A little note : the selection of container made from pottery is for avoid
reactions that may be generated from the metal container. And you should also
get soursop leaves for cancer that grow far from the urban areas, so as not
Don’t ever think badly of traditional medicine. Because so many chemical
drugs are adopting the workings of traditional medicines. It is time return to
live naturally. And knowing benefits of soursop
leaves for cancer today!.
Infusion of leaves are sudorific.
Recent studies suggest a potential for antiviral, antiparasitic and anti-cancer properties.
third-party opinions on what could turn out to be a truly remarkable
*These statements have not been evaluated by the Food and Drug
Administration (FDA) or the Medicines and Healthcare products
Regulatory Agency (MHRA). These products are not intended to
diagnose, treat, cure or prevent disease. This information is
provided for educational purposes only.* See disclaimer above.
1. Graviola Annona Muricata
By Christian Drapeau, BSc., MSc.
Common Names: Soursop, Graviola, Brazilian Paw Paw
Part Used: Leaf and fruit.
Description and Habitat: Graviola is a small tree growing
five to six meters in height with large dark green and glossy
leaves. It is indigenous to most of the warmest tropical areas in
South America, including the Amazon Basin. It produces a fruit the
size of a large cantaloupe with a delicious white flesh.
Indigenous Traditional Use: Graviola has a long history of
use by Indigenous people of the Amazon Basin who use all parts of
the Graviola tree -the bark, leaves, roots, fruits and seeds -for
various ailments. For example, the fruit and seeds are used for
intestinal health, namely to eliminate intestinal parasites and for
stomach and bowel discomforts. Women also eat paw paw (the fruit of
Graviola) or drink its juice to increase lactation. Teas are made
from the Graviola root, bark and leaves as a sedative and a nerve
tonic, as well as to help maintain healthy glucose levels. In other
parts of the world, such as the Polynesian Islands, Graviola tea is
consumed daily to elevate mood and increase quality of life.
Graviola tea taken orally or applied on the skin is also used as an
In Brazil, Indigenous people crush Graviola leaves and blend the
oozing oil from the leaves with the Graviola fruit. This preparation
is used topically for the alleviation of muscle and joint pain.
Aside from its medicinal use, Graviola fruit is eaten regularly
throughout South America as a delicious and refreshing fruit during
a hot summer day.
Scientific Studies -Mechanism of Action Many of the
indigenous applications of Graviola have been substantiated by
science, and further exceptional properties have been discovered.
First, the nerve tonic, calming and mood elevating properties of
Graviola have been demonstrated through several studies. The calming
effect on the whole body has been linked to the ability of Graviola
leaf extract to lower blood pressure.
In addition, the fruit was shown to contain a serotonin uptake
inhibitor. Serotonin is a neurotransmitter involved in the
experience of joy. When serotonin is released at the synaptic level,
stimulating the post-synaptic neuron, the effect of serotonin is
stopped by recapturing serotonin within the pre-synaptic terminal.
This process is called "reuptake:' A way of enhancing the
"joy system" in the brain and alleviating mood swings is
to increase the concentration of serotonin in the synaptic cleft by
blocking the reuptake of serotonin. Compounds that block this
process are called "serotonin reuptake inhibitors;' commonly
referred to as SRI. Several common medications are SRI. Another way
to increase the "serotonin joy system" is to consume
compounds that mimic serotonin, acting in the brain like serotonin.
An extract from the Graviola fruit was shown to contain three
compounds that act like serotonin in the brain.
Another interesting application of Graviola, well known by
Indigenous people, is its ability to repel insects. In 1988 a patent
was filed describing the insecticidal properties of annonin, a
natural compound present in Graviola. Since then, shampoo and skin
care products have been developed for the management of lice.
However, the claim to fame of Graviola is its cytotoxic
properties, which means its ability to kill cells. Cytotoxic often
refers to the ability to kill cells that are not functioning
properly and which can put the whole body at risk. More than 34
cytotoxic compounds have been isolated from Graviola, some of them
being up to 100 million times more potent than commonly used
cytotoxic compounds. The Dietary Supplement Health and Education Act
(DSHEA) prevents making health claims. Therefore, one cannot
recommend using the cytotoxic properties of Graviola for the
treatment of any disease. However, given the demonstrated properties
of Graviola, and given the role of the immune System in eliminating
dysfunctional cells, we can say that Graviola is a natural plant
that can support the functions of the immune system in an
The information contained in this article is intended for
educational purposes only. It is not intended to diagnose, cure,
mitigate, treat or prevent any disease. If you have any health
concern, it is recommended that you seek the advise of a certified
2. HEALTH SCIENCES INSTITUTE on
Members Alert for January 2001 Vol.5, No 7
Billion-dollar Drug Company Nearly Squashes Astounding Research on Natural
Colon and breast cancer conquered with miracle tree from the Amazon found to
be 10, 000 times stronger than chemotherapy.
Since our inception in 1996, Health Sciences Institute has scoured the world
to find cutting-edge treatments few people have access to or have even heard
about. And sometimes, what we uncover startles even the medical mavericks on
our board. Two months ago, we learned about an astounding cancer-fighting tree
from the Amazon that has literally sent shock waves through the HSI network.
Today, the future of cancer treatment and the chances of survival look more
promising than ever. There's a healing tree that grows deep within the Amazon
rain forest in South America that could literally change how you, your doctor,
and possibly the rest of the world think about curing cancer. With extracts
from this powerful tree, it may now be possible to... conquer cancer safely
and effectively with an all-natural therapy that doesn't cause extreme nausea,
weight loss, and hair loss protect your immune system and evade deadly
infections feel strong and healthy throughout the course of treatment boost
your energy and improve your outlook on life.
Through a series of confidential communications involving a researcher from
one of America's largest pharmaceutical companies, this ancient tree's
anticancerous properties have recently come to light. Although not yet tested
in human trials, the tree has been studied in more than 20 laboratory tests
since the 1970s, where it's been shown to: Effectively target and kill
malignant cells in 12 different types of cancer, including colon, breast,
prostate, lung, and pancreatic cancer; be 10,000 times stronger in killing
colon cancer cells than Adriamycin, a commonly used chemotherapeutic drug ;
selectively hunt down and kill cancer cells without harming healthy cells,
So why isn't every health publication extolling the benefits of this
treatment? Why hasn't it been made widely available throughout the
natural-medicine community? And, if it's only half as promising as it appears
to be, why isn't every oncologist at every major hospital insisting on using
it on all his patients? Especially when you consider that since the early
1990s, extensive independent research--including research by one of today's
leading drug companies and by the National Cancer Institute--confirms that the
tree's chemical extracts attack and destroy cancer cells with lethal
precision. Graviola is 10,000 times stronger in killing colon cancer than
Adriamycin, a commonly used chemotherapeutic drug.
The answer to these difficult questions can only be explained by recounting a
disturbing story we recently uncovered. More than anything else we've reported
on this year, the story of this Amazon cancer treatment reinforces the need
for groups like HSI and illustrates how easily our options for medical
treatment are controlled by money and power. News of this amazing tree was
nearly lost forever.
A confidential source, whose account we've been able to independently confirm,
revealed that a billion-dollar drug company in the United States tried for
nearly seven years to synthesize two of the tree's most powerful anticancerous
chemicals. In the early 1990s, behind lock and key, this well-known drug giant
began searching for a cure for cancer--while preciously guarding their
opportunity to patent it and, therefore, profit from it.
Research focused on a legendary healing tree called Graviola. Parts of the
tree--including the bark, leaves, roots, fruit, and fruit seeds--had been used
for centuries by medicine men and native Indians in South America to treat
heart disease, asthma, liver problems, and arthritis. Going on little
documented scientific evidence, the company poured money and resources into
testing Graviola's anticancerous properties--and they were shocked by the
results. Graviola was a cancer-killing dynamo. But that's where the story of
Graviola nearly ended.
The pharmaceutical company had a big problem. They'd spent years trying to
isolate and create man-made duplicates of two of the tree's most powerful
chemicals. But they'd hit a brick wall. They couldn't replicate the original.
And they couldn't sell the tree extract itself profitably-because federal law
mandates that natural substances can't be patented. That meant the company
couldn't protect its profits on the project it had poured millions of dollars
and nearly seven years of research into. As the dream of big profits
evaporated, testing on Graviola came to a screeching halt.
After seven frustrating years and without the promise of lucrative sales, the
company shelved the project and refused to publish its findings in an
independent journal. But one responsible researcher struggled with the
decision. while understanding the company's goal of profits, he couldn't
accept the decision to hide this unique cancer killer from the world.
Following his conscience and risking his career, he contacted a company
dedicated to harvesting medical plants from the Amazon Rainforest and blew the
whistle. They discovered that several other teams in the United States (in
addition to that of the drug company) had been testing Graviola in vitro (in
test tubes). The results supported the drug company's secret findings;
Graviola had been shown to kill cancer cells.
Graviola hunts down and destroys prostate, lung, breast, colon, and
pancreatic cancers... leaving healthy cells alone. Since November, we've
been looking closely into the research to date on Graviola. It appears one of
the first scientific references to it in the United States was by the National
Cancer Institute (NCI). In 1976, the NCI included Graviola in a
plant-screening program that showed its leaves and stems were effective in
attacking and destroying malignant cells. But the results were part of an
internal NCI report and were, for some reason, never released to the public.
Since 1976, there have been several promising cancer studies on Graviola.
However, the tree's extracts have yet to be tested on cancer patients. No
double-blind clinical trials exist, and clinical trials are typically the
benchmark mainstream doctors and journals use to judge a treatment's value.
Nevertheless, Graviola has been shown to kill cancer cells in vitro in at
least 20 laboratory tests that our research has uncovered.
The most recent study, conducted at Catholic University of South Korea earlier
1. Revealed that two chemicals extracted from Graviola seeds showed
"selective cytotoxicity comparable with Adriamycin" for breast and
colon cancer cells. The chemicals targeted and killed malignant breast and
colon cells in a test tube--comparable to the commonly used chemotherapy drug
2. Another study, published in the Journal of Natural Products, showed that
Graviola is not only comparable to Adriamycin--but dramatically outperforms it
in laboratory tests. Results showed that one chemical found in Graviola
selectively kill red colon cancer cells at "10,000 times the potency of
3. Graviola selectively targets cancer cells leaving healthy cells untouched.
Chemotherapy indiscriminately seeks and destroys all actively reproducing
cells - even normal, healthy ones. Other promising and ongoing research at
Purdue University is supported by a grant from the National Cancer Institute.
Purdue researchers recently found that leaves from the Graviola tree killed
cancer cells "among six human-cell lines" and were especially
effective against prostate and pancreatic cancer cells.
4. In a separate study, Purdue researchers showed that extracts from the
Graviola leaves are extremely effective in isolating and killing lung cancer
5. Perhaps the most significant result of the study cited above from the
Catholic University of South Korea, and of each of the others we've found, is
that Graviola was shown to selectively target the enemy--leaving all healthy,
normal cells untouched. By comparison, chemotherapy indiscriminately seeks and
destroys all actively reproducing cells--even normal hair and stomach cells.
This is what causes such often-devastating side effects as hair loss and
severe nausea. In this respect, Graviola looks to be a promising alternative
or supplement to mainstream treatments. Seven years of silence broken.
We are continuing to work conducting ongoing research on Graviola. As more
scientific and anecdotal evidence comes to light, you'll be among the first to
hear about it. However, after seven years of silence and hidden research, we
felt it irresponsible not to bring this to you now.
1. Unpublished data, National Cancer Institute. Anon: Nat Cancer 1st Central
from Napralert Files, University of Illinois, 1995
2. Bioorg Med Chem 8(1):285-90, 2000
3. J Nat Prod 59(2):100-108, 1996
4. Phytochemistry 49(2):565-7 1, 1998
5. J. Nat Prod 58(6):902-908, 1995
Graviola fights more than cancer:
While the research on Graviola has focused on its cancer-fighting effect, the
plant has been used for centuries by medicine men in South America to treat an
astonishing number of ailments, including:
- rashes - boils
- high blood pressure
- scurvy - fever
- muscle spasms
Despite the mounting collection of laboratory tests and anecdotal reports
about this cancer-fighting dynamo, Graviola may always remain an underground
therapy! Graviola has yet to be clinically tested on animals or humans. And
because Graviola is a natural product, it can't be patented. Without the
promise of exclusive sales and high profitability, it will likely never again
draw the attention of a major drug company or research lab. So we may never
see a double-blind clinical study on the tree that's reported to help defeat
cancer. But there's no doubt about it--the early laboratory tests and
anecdotal reports about Graviola are very exciting. And if you've been
diagnosed with cancer, you and your doctor should look at all the available
treatment options. Graviola may just provide the help you've been looking for
that could make all the difference in beating cancer.
3. Source: Herbal
Secrets of the Rainforest by Leslie Taylor
Common Names: Graviola, soursop, guanabana, guanavana, corossolier,
toge-banreisi, durian benggala, nangka blanda, nangka londa
Parts Used: Leaves, fruit, seeds, bark, roots
Medicinal Properties: Antibacterial, antiparasitic, antispasmodic,
astringent, cytotoxic, febrifuge, hypotensive, insecticide, nervine, pectoral,
piscicide, sedative, stomachic, vasodilator, vermifuge
Graviola is a small, upright evergreen tree, 5 to 6 m high, with large,
glossy, dark green leaves. It produces a large, heart-shaped edible fruit that
is 15 to 23 cm in diameter, is yellow-green in color, and has white flesh
inside. Graviola is indigenous to most of the warmest tropical areas in South
and North America, including the Amazon. The fruit is sold in local markets in
the tropics, where it is called guanabana or Brazilian cherimoya. The fruit
pulp is excellent for making drinks and sherbets and, though slightly
sour-acid, can be eaten out of hand.
All parts of the graviola tree are used in natural medicine in the tropics,
including bark, leaves, roots, fruit, and fruit-seeds. Different properties
and uses are attributed to the different parts of the tree. Generally, the
fruit and fruit juice are taken for worms and parasites, to cool fevers, to
increase mother's milk after childbirth (lactagogue) , and as an astringent
for diarrhea and dysentery. The crushed seeds are used as a vermifuge and
anthelmintic against internal and external parasites and worms. The bark,
leaves, and roots are considered sedative, antispasmodic, hypotensive, and
nervine, and a tea is made for various disorders for those purposes.
Graviola has a long, rich history of use in herbal medicine as well as a
long recorded indigenous use. In the Peruvian Andes a leaf tea is used for
catarrh (inflammation of a mucous membrane), and the crushed seed is used to
kill parasites. In the Peruvian Amazon the bark, roots, and leaves are used
for diabetes and as a sedative and antispasmodic. Indigenous tribes in Guyana
use a leaf and/or bark tea of graviola as a sedative and heart tonic. In the
Brazilian Amazon a leaf tea is used for liver problems, and the oil of the
leaves and unripe fruit is mixed with olive oil and used externally for
neuralgia, rheumatism, and arthritis pain. In Jamaica, Haiti, and the West
Indies, the fruit and/or fruit juice is used for fevers, parasites and
diarrhea and as a lactagogue, while the bark or leaves are used as an
antispasmodic, sedative, and nervine for heart conditions, coughs, grippe,
difficult childbirth, asthma, asthenia, hypertension, and parasites.
Many bioactive compounds and phytochemicals have been found in graviola, as
scientists have been studying its properties since the 1940s. Its many uses in
natural medicine have been validated by this scientific research. The earliest
studies were between 1941 and 1962. Several studies by different researchers
demonstrated that the bark as well as the leaves had hypotensive,
antispasmodic, vasodilator, smooth musclerelaxant, and cardiodepressant
activities in animals.1,2 Researchers reverified graviola leaf's
hypotensive properties in rats again in 1991.3 Several studies over
the years have demonstrated that leaf, bark, root, stem, and seed extracts of
graviola are antibacterial in vitro against numerous pathogens,4-6
and that the bark has antifungal properties.6,7 Graviola seeds
demonstrated active antiparasitic properties in a 1991 study,8 and
a leaf extract showed to be active against malaria in two other studies, in
1990 and 1993. 9,10 The leaves, root, and seeds of graviola
demonstrated insecticidal properties, with the seed demonstrating strong
insecticidal activity in an early 1940 study;11 In a 1997 clinical
study, novel alkaloids found in graviola fruit exhibited antidepressive
effects in animals.12
Much of the recent research on graviola has focused on a novel set of
phytochemicals found in the leaves, seeds, and stem that are cytotoxic against
various cancer cells. In a 1976 plant screening by the National Cancer
Institute, the leaves and stem of graviola showed active cytotoxicity against
cancer cells, and researchers have been following up on this research ever
since.13 Two separate research groups have isolated novel compounds
in the seeds and leaves of the plant that have demonstrated significant
antitumorous, anti- cancerous, and selective toxicity activity against various
types of cancer cells; the research groups have published eight clinical
studies on their findings.14-21 One study demonstrated that an
isolated compound in graviola was selectively cytotoxic to colon
adenocarcinoma cells, showing that it had 10,000 times the potency of
adriamycin, a leading chemotherapy drug.15
Suggested Usage: Natural health practitioners use graviola bark and
leaves for many natural remedies, especially as a heart tonic, as a nervine,
and for disorders of a bacterial nature such as colds and flu, and even
cancer. The therapeutic dosage is reported to be 3 to 4 grams daily of the
leaves and/or bark, and sometimes a standard infusion is used in 1/2-cup
dosages 1 to 3 times daily.
1. Feng, P.C., et al. "Pharmacological screening of some West Indian
medicinal plants." I. Pharm. Pharmacol. 14 (1962): 556-61.
2. Meyer, T. M. "The alkaloids of Annona muricata." Ing. Ned. Indie.
8,6 (1941): 64. 3. Carbajal, D., et al. "Pharmacological screening of
plant decoctions commonly used
in Cuban folk medicine." I. Ethnopharmacol. 33,1/2 (1991): 21-4.
4. Misas, C. A. J., et al. "Contribution to the biological evaluation of
Cuban plants. IV." Rev. Cubana Med. Trop. 31,1 (1979): 29-35.
5. Sundarrao, K, et al. "Preliminary screening of antibacterial and
antitumor activi- ties of Papua New Guinean native medicinal plants."
Int. I. Pharmacog. 31, 1 (1993): 3-6.
6. Heinrich, M., et al. "Parasitological and microbiological evaluation
of Mixe Indian medicinal plants (Mexico)." I. Ethnopharmacol. 36,1
7. Lopez, Abraham A. M. "Plant extracts with cytostatic properties
growing in Cuba. I." Rev. Cubana Med. Trop. 31,2 (1979): 97-104.
8. Bories, C. Et al. "Antiparasitic activity of Annona muricata and
Annona cherimo- lia seeds." Planta Med. 57,5 (1991): 434-36.
9. Antoun, M.D., et al. "Screening of the flora of Puerto Rico for
potential antimalar- ial bioactives." Int. I. Pharmacog. 31,4 (1993):
10. Gbeassor, M., et al. "In vitro antimalarial activity of six medicinal
plants." Phytother. Res. 4,3 (1990): 115-17.
11. Tattersfield, F., et al. "The insecticidal properties of certain
species of Annona and an Indian strain of Mundulea sericea (Supli)." Ann.
Appl. Bioi. 27 (1940): 262-73.
12. Hasrat, J. A., et al. "Isoquinoline derivatives isolated from the
fruit of Annona muricata as 5-HTergic 5-HTIA receptor agonists in rats:
unexploited antidepres- sive (lead) products." I. Pharm. Pharmacol. 49,11
(November 1997): 1145-49.
13. Unpublished data, National Cancer Institute. Anon: Nat Cancer Inst Central
Files (1976). From Napralert Files, University of Illinois, 1995.
14. Zeng, L., et al. "Five new monotetrahydrofuran ring acetogenins from
the leaves of Annona muricata." I. Nat. Prod. 59,11 (November 1996):
15. Rieser, M. J., et al. "Five novel mono-tetrahydrofuran ring
acetogenins from the seeds of Annona muricata." I. Nat. Prod. 59,2
(February 1996): 100-8.
16. Wu, F. E., et al. "Additional bioactive acetogenins, annomutacin and
(2,4-trans and cis)-10R-annonacin-A-ones, from the leaves of Annona muricata."
I. Nat. Prod. 58,9 (September 1995): 1430-37.
17. Wu, F. E., et al. "New bioactive monotetrahydrofuran Annonaceous
acetogenins, annomuricin C and muricatocin C, from the leaves of Annona
muricata." I. Nat. Prod.58,6 (June 1995): 909-15.
18. Wu, F. E., et al. "Muricatocins A and B, two new bioactive
monotetrahydrofuran Annonaceous acetogenins from the leaves of Annona muricata."
I. Nat. Prod. 58, 6 (June 1995): 902-8.
19. Wu, F. E., et al. "Two new cytotoxic monotetrahydrofuran Annonaceous
aceto- genins, annomuricins A and B, from the leaves of Annona muricata."
I. Nat. Prod. 58,6 (June 1995): 830-36.
20. Rieser, M. J., et al. "Bioactive single-ring acetogenins from seed
extracts of Annona muricata." Planta Med. 59, 1 (February 1993): 91-2.
21. Rieser, M. J., et al. "Muricatacin: a simple biologically active
acetogenin deriva- tive from the seeds of Annona muricata (Annonaceae)."
Tetrahedron Lett. 32,9 (1991): 1137-40.
4. Medicine From the
Rainforest - Graviola
By Dr. Robert D. Willix, Jr.
Health & Longevity Newsletter, March 2003, Vol. 10, No. 3
The rainforest is home to a remarkable natural pharmacy that
never ceases to amaze me.
Although I've studied the indigenous healing tradition of the Amazon for
years, I find there is always some new discovery waiting for me. The latest
find is graviola, a small evergreen tress that grows throughout Peru, Guyana
Although I've only recently learned of its incredible healing properties,
graviola has a long, rich history of use among medicine men in the region.
Traditionally used to treat arthritis, asthma, diabetes and heart disease,
news of this herb is causing unprecedented excitement among researchers here
in America. It seems that graviola is one of the most potent cancer killers
ever found. Laboratory tests from Perdue University and the Catholic
University of South Korea have shown that graviola effectively targets and
kills malignant cells in 12 different types of cancer, including colon,
breast, prostate, lung and pancreatic cancer. In one study, published in the
Journal of Natural Products, researchers found that one of the chemicals found
in the miraculous tree killed colon cancer cells at "10,000 times the
potency of Adriamycin," a commonly used chemotherapy drug. And unlike
chemotherapy, graviola selectively hunts down an kills cancer cells without
harming healthy cells. It's so effective that the National Cancer Institute
has confirmed that the tree's chemical extracts attack and destroy cancer
cells with lethal precision!
If graviola has the potential to wield such a deathblow to cancer, why
haven't you heard of it? Because most of the research was sponsored by a major
pharmaceutical company, who, after years of unsuccessfully trying to
synthesize the active agents in graviola, attempted to bury their findings!
Because the natural poser of graviola can't be artificially replicated in a
test tube, clinical trials have yet to be conducted. It just isn't profitable.
Thank goodness the natural products industry puts people before profit.
Because graviola is a natural remedy, it is protected under the Dietary
Supplement Health and Education Act of 1994. Consequently, a number of
companies are making this wonderful cancer fighter available to cancer
victims. Most base their dosage on the traditional South American
recommendation of 1,000 to 1,500 mg. per day. While graviola doesn't have any
side effects, pregnant women, people with low blood pressure or those taking
MAO inhibitors should not use it.
From "Graviola-Monograph.pdf" 03/01/04
Please see the full .PDF file at: http://www.rain-tree.com/graviola.htm
© Copyrighted 2004. Raintree Nutrition, Inc. Carson City NV 89701 All rights reserved.
Graviola Monograph 03/01/04
Synonyms: Annona macrocarpa, A. bonplandiana, A. cearensis, Guanabanus muricatus
Standard Common Name: Soursop - North American (Herbs of Commerce, 2 nd edition)
Other Common Names: Graviola, guanábana (Herbs of Commerce, 2 nd edition)
Additional Common Names:
Graviola - Brazil
Guanábana - Spanish
Guanábano - Spanish
Guanavana - Spanish
Guanaba - Spanish
Corossol - French
Epineux - French
Huanaba - Spanish
Toge-Banreisi - Taiwanese
Durian benggala - Indian
Nangka blanda - Indian
Cachiman épineux - French
Sauersack - German
Stachelannone - German
Graviola is a small, upright tropical evergreen tree, 5-6 m high, with large, glossy, dark green leaves. It
produces a large, heart-shaped, edible fruit that is 15-23 cm in diameter, is yellow-green in color and has
white flesh inside. The fruit is popular in South America.
All parts of the graviola tree have been used medicinally in traditional herbal medicine. Traditional herbal
medicine practitioners have attributed graviola with the following properties and actions: anthelmintic,
antiparasitic, antipyretic, sedative, antispasmodic, nervine, hypotensive, anticonvulsant and digestive.
The traditional use of graviola has been recorded in herbal medicine systems in the following countries:
Amazonia,1 Barbados,2 Borneo,3 Brazil,4-8 Cook Islands,9 Curacao,10 Dominica,11 Guatemala,12 Guam,13
Guyana,14 Haiti,15,16 Jamaica,17,18 Madagascar,19 Malaysia,20,21 Peru,22,26 Suriname,27 Togo 28 and West
Summary of Traditional Uses of Graviola:31
Flower: Bronchitis, cough.
Fruit: Colit is, diarrhea, dysentery, fevers, hydropsy, juice, lactogogue, mouth sores, parasites,
Seeds: Astringent, carminative, emetic, head lice, insecticide, parasites, skin parasites, worms.
Bark: Asthenia, asthma, childbirth, cough, diabetesgrippe, heart tonic, hypertension, nervine,
parasites, sedative, spasms.
Leaf: Abscesses, arthritis pain, asthenia, asthma, astringent, bronchitis, catarrh, colic, cough,
diabetes, diuretic, dysentery, edema, fever, gallbladder disorders, grippe, heart, hypertension,
indigestion, infections, intestinal worms, lactogogue, liver disorders, malaria, nervine,
nervousness, neuralgia, palpitations, parasites, parturition, rashes, rheumatism, ringworm,
sedative, skin disorders, spasms, styptic, tonic, tranquilizer, tumors, ulcers, worms.
Root: Diabetes, sedative, spasms.
Rootbark: Calmative, diabetes, spasms.
Primary Uses in Traditional Herbal Medicine Systems
Graviola is primarily employed in traditional herbal medicine systems for parasitic infections and
cancer.22,25,32,33,24 It has also been used in some herbal medicine systems for its sedative and antispasmodic
Phytochemically graviola is rich in miscellaneous lactones and isoquinoline alkaloids. The leaf, stem, bark
and seeds of graviola contain varying amounts of a novel group of chemcials believed to be biologically
active, called Annonaceous acetogenins.
The annonaceous acetogenins in graviola include:
annomuricatin A & B,
annomuricin A thru E,
annopentocin A thru C,
cohibin A thru D,
epomuricenin A & B,
gigantetrocin A & B,
muracin A thru G,
muricatetrocin A & B
muricatocin A thru C
murihexocin A thru C,
rolliniastatin 1 & 2,
uvariamicin I & IV,
Various acetogenins in graviola have been documented with the following biological activity:
10 mg/kg of annonacin was given intraperitoneally in mice with Lewis lung cancer; a 57.9% inhibition was
In vitro studies are numerous. Following are select in vitro studies where acetogenins were utilized against
various cell lines:
• Human hepatoma hep G(2), 2, 2, 15 cell lines. A CC50=49.5 mcg/ml was seen in one study.35-38
• Six human tumor cell lines.39-41
• Prostate adenocarcinoma PC-3. 39,40
• Pancreatic carcinoma PACA-2. 39,40
• Murine leukemia L1210 and P388 leukemia.30,42,43
• Human breast adenocarcinoma MDA-MB231 and carcinoma MCF-7. 40,42,44
• Human tumor multidrug-resistant SW480 (P-glycoprotein+, Pgp+) tumor cells.45
• Human lung carcinoma A-549. 44
• Human colon cancer HT-29. 44
• Various cancer cell lines; growth was inhibited 50% at concentrations of <10-12 ug/ml.46
• Adriamycin resistant tumor cells (M17/adr breast cancer cells); Non-adriamycin resistant tumor cells.47
• Annonacin was able to kill various cancer cell lines at an IC50=<4 ug/mL.48
Acetogenins have shown inhibition of tumor cell growth towards adriamycin resistant human mammary
adenocarcinoma MCF-7/Adr cells.43,49
Antimicrobial and Antiprotozoal Activity
Methanol, hexane and ethyl acetate extracts of the seed, stem, bark and pericarp have demonstrated in vitro
antiparasitic activity against E. histolytic, N. brasiliensis, M. dessetae, A. salina, Leishmania trypansoma, L.
braziliensis, L. panamensis and L. promastigotes.34,59,68
Ethanol leaf extracts have shown in vitro antimalarial activity against Plasmodium falciparum D-6 & W-2
at IC50=20 - 63 mcg/ml.3,28,69
Leaf, stem and bark water, acetone, methanol and ethanol extracts have demonstrated in vitro antibacterial
activity at concentrations of 2-3 mcg/plate to 1 mg/disc. Organisms the extracts are active against include:
E. coli, P. aeruginosa, S. flexneri, S. spp., S. marcescens, S. aureus, S. albus, S. newport, B. subtilis.70-72
A water soluble fraction from the stem had an antiproliferative effect on HIV-infected cells in vitro at
IC50=<2mcg/ml.73 The stem and bark in an ethanol extract at 1 mg/ml had in vitro activity against herpes
simplex 1, whil e the root had activity against herpes simplex type 2 in vitro at CC50 and EC50=0.5
Stem, bark and leaf ethanol extracts have demonstrated in vitro activity against B. glabrata at LD50-0.97-
The leaf had activ ity against the following insects in vitro: M. sanborni, L. decemlineata, M. persicae, Blatella
Stem and bark ethanol extracts at 100 mg/kg intragastrically in rats had antiulcer activity.76
Stem and bark ethanol extracts at 100 mg/kg intragastrically in rats had antioxidant activity.77
A leaf decoction reduced ASAT leakage by hepatocytes in vitro at 1 mg/plate.78
Anticancerous and cytotoxic effects of graviola are attributed to the annonaceous acetogenins which
have a number of mechanisms including:
• Inhibition of NADH oxidase in the plasma membranes of cancer cells. This enzyme is only
transiently expressed in ‘normal healthy’ cells. By inhibiting this enzyme cellular ATP is
• Inhibition of complex I (NADH:ubiquinone oxidoreductase) in mitochondrial electron transport
systems, inhibiting oxidative phosphorylation and resulting in lower ATP levels, hence
inhibiting cancer cell growth.46,80-83
• Inhibition of cancer cells that are multidrug resistant. Increased expression of a plasma
membrane pump, P-glycoprotein, is a contributor to multidrug resistance. The pump ensures
elimination of the anticancer compound before it can have its effect on the cancer cell. Two
intracellular ATP-binding sites are found on P-glycoprotein, and the pump activity requires
ATP. The acetogenins, through depletion of ATP, can reduce the activity or shut down the P-glycoprotein
• Cancer cells at the S phase of their cell cycle are more vulnerable to the acetogenin
annonacin. Annonacin is able to arrest the cell cycle in the G1 phase, and inhibit the S phase
progression. In addition p53 and p21, cell cycle checkpoint proteins, were enhanced by
• The acetogenin annonacin is able to induce apoptotic cell death. It enhanced the expression of
Bax and Bad, but not Bcl-2 or Bcl-xL.48
Through the above mechanisms of action the acetogenins are able to decrease oxidative
phosphorylation and cytosolic ATP production. Deprivation of the cancer cells ATP results in apoptosis of
the cancer cell.46,80
Antidepressant, sedative and tranquilizing properties of graviola may be due to the ability of certain alkaloids
to have agonistic properties towards 5-HT1A receptors in calf hippocampus.85
Cold immobilization stress in rats causes depletion of norepinephrine and dopamine levels in the brain. It
also decreases MAO (monoamine oxidase) activity which leads to increases in 5-HT and 5-HIAA levels. Pre-treatment
with graviola prevented the stress-induced depletion of norepinephrine and dopamine, helping the
organism cope better during stress. In addition pre-treatment with graviola reduced the stress-induced rise
in brain 5-HT and 5-HIAA, and increased MAO activity. It was concluded that graviola had a normalizing
effect in rats against a variety of stressors, indicating it had adaptogenic potential.67
The potential neurotoxic effect of the seeds, root and rootbark is discussed under Chemicals.
Graviola has insecticidal activity which is attributed to the acetogenins. They are suggested for use in the
control of insect pests such as cockroaches. Pest ingestion of the acetogenins produces mortality in both
susceptible and insecticidal/pesticidal-resistant cockroaches. The effectiveness of the acetogenins against
insecticial/pesticidal-resistant insects suggests that pesticide-resistance is associated with ATP-dependent
The activity of graviola is mainly attributed to the acetogenins, which are mitochondrial respiratory chain
complex I inhibitors.52
Crude Preparations, Leaf and Stem
2 grams three times daily
Infusion: 1 cup (150 ml) boiling water poured over approximately 2 grams of dried leaf and stem and
steep, covered, for 5-10 minutes, 3 times daily between meals
Tincture: Of a 1:2 tincture take 2-4 ml three times daily
Duration of Administration
Long-term administration (6 months) with no health complaint may deplete healthy cells of ATP. Duration
of administration varies per complaint and individual.
Pregnancy and Lactation: Graviola has documented uterine stimulant activ ity in an animal study (rats)
and should not be used during pregnancy.62
Graviola has demonstrated hypotensive, vasodilator, and cardiodepressant activities in animal studies
and is contraindicated for people with low blood pressure.63
Graviola may potentiate antihypertensive and cardiac depressant drugs.63,64
It may potentiate antidepressant drugs and interfere with MAO-inhibitor drugs.66,67
Co-enzyme Q10 may reduce the activity of graviola. Coenzyme Q10 is required for the function of the
ubiquinone oxidoreductase, which graviola has been shown to inhibit.46,80-83
Graviola has demonstrated emetic properties in one animal study with pigs. Large single dosages may cause
nausea or vomiting.31
Alcohol extracts of graviola leaf showed no toxicity or side effects in mice at 100 mg/kg intraperitoneally;
however, at a dosage of 300 mg/kg, a reduction in explorativ e behavior and mild abdominal constrictions
Alkaloids in the rootbark, root and seed of graviola have been linked to a levodopa-resistant parkinsonism.
In vitro studies show they cause DNA damage and apoptosis of dopaminergic cells and GABAergic
neurons.50 Excessive consumption of these parts of the plant should be avoided.
1. Schultes, R. E. And Raffauf. The Healing Forest: Medicinal and Toxic plants of the Northwest
Amazonia. Portland: R. F. Dioscorides Press. 1990.
2. Morton, J. F. “Caribbean and Latin American Folk Medicine and its Influence in the United States.”
Q. J. Crude Drug Res. 1980; 18(2): 57-75.
3. Leaman, D. J., et al. “Malaria remedies of the Kenyah of the Apo Kayan, East Kalimantan,
Indonesian Borneo: A quantitiativ e assessment of local consensus as an indicator of biological
efficacy.” J. Ethnopharmacol. 1995; 49(1): 1-16.
4. Caribé, Dr. José, and Dr. José Mariá Campos. Plantas Que Ajudam O Homem: Guia Prático Para
a Época Atual, 5th Ed. São Paulo, Brazil: Editora Pensimento, Ltda., 1997.
5. Branch, L.C. and Da Silva, I.M. F. “Folk Medicine of Alter Do Chao, Para, Brazil.” Acta Amazonica
6. Santos, A. F., et al. “Molluscicidal properties of some species of Annona.” Phytomedicine 2001;
7. De Almeida, E.R. Plantas Medicinais Brasileiras, Conhecimentos Populares E Cientificos. Hemus
Editora Ltda. Sau Paulo, Brazil. 1993.
8. Mors, W. B., et. al. Medicinal plants of Brazil. Algonac, Michigan, Reference Publications, Inc.,
9. Holdsworth, D. K. “Traditional Medicinal Plants of Rarotonga, Cook Islands.” Part I. Int. J. Crude
Drug Res. 1990; 28(3): 209-218.
10. Morton, J. F. “A survey of medicinal plants of Curacao.” Econ. Bot. 1968; 22 : 87-.
11. Haddock, R. L. “Some medicinal plants of Guam including English and Guamanian common
names.” Report Regional Tech Mtg Med Plants, Papeete, Tahiti, Nov, 1973; South Pacific
Commission, Noumea, New Caledonia 1974 : 79.
12. Caceres, A., et al. “Plants used in Guatemala for the treatment of dermatophytic infections. 1.
screening for antimycotic activity of 44 plant extracts.” J. Ethnopharmacol. 1991; 31(3): 263-276.
13. Hodge, W. H., et al. “The ethnobotany of the Island Caribs of Dominica.” Webbia 1956; 12:
14. Grenand, P., et al. “Pharmacopees taditionnels en Guyane: Créoles, Palikur, Wayãpi.” Editorial
L-Orstrom, Coll. Mem No. 108. Paris, France 1987.
15. Weniger, B. et al. “Popular medicine of the Central Plateau of Haiti. 2. Ethnopharmacological
Inventory.” J. Ethnopharmacol. 1986; 17(1): 13-30.
17. Asprey, G. F., et al. “Medicinal plants of Jamaica. III.” West Indian Med. J. 1955; 4: 69-92.
19. Novy, J. W. “Medicinal plants of the Eastern Region of Madagascar.” J. Ethnopharmacol. 1997; 55
20. Ahmad, F. B., et al. “Medicinal plants of Sabah, Malaysia, Part II. The Muruts.” Int. J. Pharmacog.
1994; 32(4): 378-383.
21. Ilham, M., et al. “Tumour promoting activity of plants used in Malaysian traditional medicine.” Nat.
Prod. Sci. 1995; 1(1): 31-42.
22. Zadra, de, Adriana Alarco. Perú—El libro de las plantas mágicas, 2nd Ed. Lima: Concytec, 2000.
23. Duke, J. A. Amazonian Ethnobotanical Dictionary. Book 1994: 181-.
24. Vasquez, M. R. Useful plants of Amazonian Peru. Second Draft.. 1990.
25. De Feo, V. “Medicinal and magical plants in the Northern Peruvian Andes.” Fitoterapia 1992; 63:
26. Zadra, de, Adriana Alarco. Perú—El libro de las plantas mágicas, 2nd Ed. Lima: Concytec, 2000.
27. Hasrat, J. A., et al. “Isoquinoline derivatives isolated from the fruit of Annona muricata as
5-HTergic 5-HT1a receptor agonists in rats: unexploited antidpressive (lead) products.” J. Pharm.
Pharmacol. 1997; 49(11): 1145-1149.
28. Gbeassor, M., et al. “In vitro antimalarial activity of six medicinal plants.” Phytother. Res. 1990;
29. Ayensu, E. S. “Medicinal plants of the West Indies.” Unpublished Manuscript 1978; 110 P-.
31. Technical Data Report for Graviola (Annona muricata). Sage Press, Inc. 2002.
32. Anon. Unpublished Data, National Cancer Institute. Nat. Cancer Inst. Central Files. 1976.
33. Ye, Q., et al. “Longifolicin, longicoricin and gigantetroneninone, three novel bioactive mono-tetrahydrofuran
annonaceous acetogenins from Asimina longifolia (Annonaceae).” Bioorg. Med.
Chem. 1996; 4(4): 537-4.
34. Wang, L. Q., et al. “Annonaceous acetogenins from the leaves of Annona montana.” Bioorg. Med.
Chem. 2002; 10(3): 561-5.
35. Chang, R. F., et al. “Novel cytotoxic annonaceous acetogenins from Annona muricata.” J. Nat.
Prod. 2001; 64(7): 925-31.
36. Chang, F. R., et al. “New adjacent bis-tetrahydrofuran annonaceous acetogenins from Annona
muricata.” Planta Med. 2003; 69(3): 241-6.
37. Liaw, C. C., et al. “New cytotoxic monotetrahydrofuran annonaceous acetogenins from Annona
muricata.” J. Nat. Prod. 2002; 65(4): 470-5.
38. Betancur-Galvis, L., et al. “Antitumor and antiviral activity of Colombian medicinal plant extracts.”
Mem. Inst. Oswaldo Cruz. 1999; 94(4): 531-5.
39. Woo, M. H., et al. “Cis-annonacin and (2,4)-cis-and trans-isoannonacins: cytotoxic
monotetrahydrofuran annonaceous acetogenins from the seeds of Annona cherimolia.” Arch.
Pharm. Res. 1999; 22(5): 524-8.
40. Kim, G. S., et al. “Muricoreacin and murihexocin c, mono-tetrahydrofuran acetogenins, from the
leaves of Annona muricata.” Phytochemistry 1998; 49(2): 565-571.
41. Fang, X. P., et al. “Gigantetronenin and gigantrionenin: novel cytotoxic acetogenins from
Goniothalamus giganteus.” J. Nat. Prod. 1992; 55(11): 1655-63.
42. Jossang, A., et al. “Annomonysvin: a New cytotoxic gamma-lactone-monotetrahydrofuranyl
acetogenin from Annona montana.” J. Nat. Prod. 1991; 54(4): 967-71.
43. Oberlies, N. H., et al. “Structure-activ ity Relationships of diverse annonaceous acetogenins against
multidrug resistant human mammary adenocarcinoma (MCF-7/ADR) cells.” J. Med. Chem. 1997;
44. Zhao, G. X., et al. “Biologically active acetogenins from stem bark of Asimina triloba.”
Phytochemistry 1993; 33(5): 1065-73.
45. Gonzalez-Coloma. A., et al. “Selective action of acetogenin mitochondrial complex I inhibitors.”
Naturforsch 2002; 57(11-12): 1028-34.
46. Feras, Q., et al. “Annonaceous acetogenins: Recent progress.” J. Nat. Prod. 1999; 62(3): 504-540.
47. Oberlies, N. H., et al. “Tumor cell growth inhibition by several annonaceous acetogenins in an in
vitro disk diffusion assay.” Cancer Lett. 1995; 96(1): 55-62.
48. Yuan, Shyng-Shiou F., et al. “Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells
at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway.” Life Sciences
2003; 72: 2853-2861.
49. Abraham, A. M. “Plant extracts with cytostatic properties growing in Cuba.” Rev. Cubana Med.
Trop. 1979; 31(2): 97-104.
50. Lannuzel, A., et al. “Toxicity of Annonaceae for dopaminergic neurons: potential role in atypical
parkinsonism in Guadeloupe.” Mov. Disord. 2002; 17(1): 84-90.
51. Caparros-Lefebvre, D., et al. “Possible relation of atypical parkinsonism in the French West Indies
with consumption of tropical plants: a case-control study. Caribbean Parkinsonism Study Group.”
Lancet 1999; 354(9175): 281-6.
52. Lannuzel, A., et al. “The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic
dopaminergic neurons by impairment of energy metabolism.” Neuroscience 2003; 121(2): 287-296.
53. Tattersfield, F., et al. “The insecticidal properties of certain species of Annona and an Indian strain
of Mundulea sericea (Supli).” Ann. Appl. Biol. 1940; 27: 262-273.
54. Guadano, A., et al. “Insecticidal and mutagenic evaluation of two annonaceous acetogenins.” J.
Nat. Prod. 2000; 63(6): 773-6.
55. Alali, F. Q., et al. “Annonaceous acetogenins as natural pesticides; potent toxicity against
insecticide-susceptible and resistant german cockroaches (Dictyoptera: blattellidae).” J. Econ.
Entomol. 1998; 91(3): 641-9.
56. Zeng, L., et al. “Five new monotetrahydrofuran ring acetogenins from the leaves of Annona
muricata.” J. Nat. Prod. 1996; 59(11): 1035-1042.
57. Kim, G. S., et al. “Two new mono-tetrahydrofuran ring acetogenins, annomuricin E and
muricapentocin, from the leaves of Annona muricata.” J. Nat. Prod. 1998; 61(4): 432-436.
58. Betancur-Galvis, L., et al. “Antitumor and antiviral activity of Colombian medicinal plant extracts.”
Mem. Inst. Oswaldo Cruz 1999; 94(4): 531-535.
59. Jaramillo, M. C., et al. “Cytotoxicity and antileishmanial activity of Annona muricata pericarp.”
Fitoterapia. 2000; 71(2): 183-6.
60. Li, D. Y., et al. “Annonaceous acetogenins of the seeds from Annona muricata.” J. Asian Nat. Prod.
Res. 2001; 3(4): 267-76.
61. Wu, F. E., et al. “Two new cytotoxic monotetrahydrofuran annonaceous acetogenins, annomuricins
a and b, from the leaves of Annona muricata.” J. Nat. Prod. 1995; 58(6): 830-836.
62. Feng, P. C., et al. “Pharmacological screening of some West Indian medicinal plants.” J. Pharm.
© Copyrighted 2004. Raintree Nutrition, Inc. Carson City NV 89701 All rights reserved.
Pharmacol. 1962; 14 : 556-561.
63. Carbajal, D., et al. “Pharmacological screening of plant decoctions commonly used in Cuban folk
medicine.” J. Ethnopharmacol. 1991; 33(1/2): 21-24.
64. Meyer, T. M. “The alkaloids of Annona muricata.” Ing. Ned. Indie. 1941; 8(6): 64-.
65. N'Gouemo, P., et al. “Effects of ethanol extract of Annona muricata on pentylenetetrazol-induced
convulsive seizures in mice.” Phytother. Res. 1997; 11(3): 243-245.
66. Hasrat, J. A., et al. “Screening of medicinal plants from Suriname for 5-HT 1a ligands: bioactive
isoquinoline alkaloids from the fruit of Annona muricata.” Phytomedicine 1997; 4(2): 133-140.
67. Padma, P., et al. “Effect of Annona muricata and Polyalthia cerasoides on brain neurotransmitters
and enzyme monoamine oxidase following cold immobilization stress.” J. Natural Remedies 2001;
68. Bories, C., et al. “Antiparasitic activity of Annona muricata and Annona cherimolia seeds.” Planta
Med. 1991; 57(5): 434-436.
69. Antoun, M. D., et al. “Screening of the flora of Puerto Rico for potential antimalarial bioactives.” Int.
J. Pharmacog. 1993; 31(4): 255-25.
70. Misas, C. A. J., et al. “Contribution to the biological evaluation of Cuban plants. IV.” Rev. Cub.
Med. Trop. 1979; 31(1): 29-35.
71. Sundarrao, K., et al. “Preliminary screening of antibacterial and antitumor activities of Papua New
Guinean native medicinal plants.” Int. J. Pharmacog. 1993; 31(1): 3-6.
72. Khan, M. R., et al. “Antibacterial activity of some annonaceae. Part I.” Fitoterapia 1998; 69(4):
73. Antoun, M. D., et al. “Evaluation of the flora of Puerto Rico for in vitro cytotoxic and anti-HIV
activities.” Pharmaceutical Biol. 1999; 37(4): 277-280.
74. Padma, P., et al. “Effect of the extract of Annona muricata and Petunia nyctaginiflora on herpes
simplex virus.” J. Ethnopharmacol. 1998; 61 1: 81-83.
75. Dos Santos, A F., et al. “Molluscicidal properties of some species of Annona.” Phytomedicine.
2001; 8(2): 115-20.
76. Padma, P., et al. “Effect of some indigenous drugs on cold immobilization stress induced gastric
ulcer.” Phytother. Res. 1998; 12(2): 127-128.
77. Padma, P., et al. “Effect of alcohol extract of Annona muricata on cold immobili zation stress
induced tissue lipid peroxidation.” Phytother. Res. 1997; 11(4): 326-327.
78. Joyeux, M., et al. “Screening of antiradical, antilipoperoxidant and hepatoprotective effects of nine
plant extracts used in Caribbean folk medicine.” J. Phytother. Res. 1995; 9(3): 228-230.
79. Morre, D. J., et al. “Mode of action of bullatacin, a potent antitumor acetogenin: inhibition of NADH
oxidase activity of HeLa and HL-60, but not liver, plasma membranes.” Life Sci. 1995; 56(5): 343-
80. Oberlies, N. H., et al. “Structure-activ ity relationships of diverse annonaceous acetogenins against
multidrug resistant human mammary adenocarcinoma (MCF-7/Adr) cells.” J. Med. Chem. 1997;
81. Tormo, J. R., et al. “Epoxy-acetogenins and other polyketide epoxy derivatives as inhibitors of the
mitochondrial respiratory chain complex I.” Planta Med. 2000; 66(4): 318-23.
82. Tormo, J. R., et al. “Kinetic characterization of mitochondrial complex I inhibitors using
annonaceous acetogenins.” Arch. Biochem. Biophys. 1999; 369(1): 119-26.
83. Alali, F. Q., et al. “Annonaceous acetogenins: recent progress.” J. Nat. Prod. 1999; 62(3): 504-40.
84. Gonzalez-Coloma, A., et al. “Selective action of acetogenin mitochondrial complex I inhibitors.” Z.
Naturforsch 2002; 57(11-12): 1028-34.
85. Hasrat, J. A., et al. “Isoquinoline derivatives isolated from the fruit of Annona muricata as 5-Htergic
5-HT1A receptor agonists in rats: unexploited antidepressive (lead) products.” J. Pharm.
Pharmacol. 1997; 49(11): 1145-9.
Why Selling Natural Products is Such a Dangerous Business To legally market a drug (that is, any substance that can claim to cure, prevent, mitigate, or treat a disease), it must go through the lengthy and expensive FDA drug approval process. Any violation - that is, any sale of a "drug" that is not FDA-approved - can lead to seizure of the product, injunctions against its sale and distribution, and criminal penalties, including imprisonment, for the manufacturer.
Soursop Fruit 100 Fold Stronger At Killing Cancer Than Chemotherapy. Besides being a cancer remedy, graviola is a broad spectrum antimicrobial agent for both bacterial and fungal infections, is effective against internal parasites and worms, lowers high blood pressure and is used for depression, stress and nervous disorders.
The Health Benefits of Cloves. The active principles in the clove are known to have antioxidant, anti-septic, local anesthetic, anti-inflammatory, rubefacient (warming and soothing), carminative and anti-flatulent properties.
Comfrey. Healing for wounds, and helpful in high blood pressure, diabetes, and more.
Cardamonin, inhibits pro-inflammatory mediators in activated RAW 264.7 cells and whole blood. Cardamonin acts upon major pro-inflammatory mediators.
Chelerythrine. Chelerythrine is a benzophenanthridine alkaloid extracted from the plant Greater celandine (Chelidonium majus) and from Blood Root (Sanguinaria canadensis). It is a potent, selective, and cell-permeable protein kinase C inhibitor (may improve mood and benefit the heart, is used in several anti-cancer drugs).
What is Nigella Sativa? (Jintan Hitam). Black seed is used for treating gastrointestinal conditions including gas, colic, diarrhea, dysentery, constipation and haemorrhoids. It is also used for respiratory conditions, including asthma, allergies, cough, bronchitis, emphysema, flu and congestion. Additionally, it is used as an antihypertensive, immunoprotectant, anticancer agent, and vermifuge.
About BSI Mangiferin. The colorful history of Mangiferin dates more than 1000 years, a mainstay of Chinese medicine, Balean medicine in Indonesia, and ethno-medicine in Cuba.
Keladi tikus / Typhonium flagelliforme (Lodd.) Bl. The type of cancer that can be inhibited by rodent tuber is in addition to breast cancer nasopharyngeal cancer, liver, cancer of the cervix, pancreas, prostate, lung and many more. In addition to cancer, according to some studies also mentioned that taro rats can be used for people who have drug addiction.
Noni Fruit and Juice and its Benefits. Noni mimics the secretion coming from the pineal gland, and in fact acts as a precursor to it, building it up and allowing it to function fully. It is a noted analgesic or pain reliever.
California Poppy. The California poppy contains protopine, which has similar (but much milder effects) as morphine, making it a good natural sedative.
Research: Pineapple Bromelain Enzyme Kills Cancer Without Killing You. How then, can something as innocuous as the enzyme from the stem/core of a pineapple be superior to a drug that millions of cancers patients over the past 40 years have placed their hopes of recovery on, as well as exchanging billions of dollars for?
Health Benefits of Aloe Vera. Not only does it contain vitamin B12 but several other minerals that are important for the health of our bodies. Aloe vera also contains calcium, protein, zinc, magnesium, vitamins A, and E, germanium, essential fatty acids and amino acids.
The Magic Duo for Cancer Treatment That Frightens The FDA and Conventional Medicine: DMSO.Dimethyl sulfoxide (DMSO), a by-product of the wood industry, has been in use as a commercial solvent since 1953. DMSO can carry other drugs with it across membranes. It is more successful ferrying some drugs, such as morphine sulfate, penicillin, steroids, and cortisone, than others, such as insulin. What it will carry depends on the molecular weight, shape, and electrochemistry of the molecules. This property would enable DMSO to act as a new drug delivery system that would lower the risk of infection occurring whenever skin is penetrated.
6 Benefits of Papaya Leaves to the Human Body One supplement you should not overlook is Papaya Leaf Extract. Papayas are excellent sources of dietary fiber, vitamin C, vitamin A, vitamin E, and folate, while at the same time being rich in antioxidants, flavonoids, and carotenes. Papayas also contain high amounts of enzymes called papain and chymopapain, which are critical ingredients for a healthy body.
Health Benefits of Pine Essential Oil. The health benefits of pine essential oil include its ability to reduce inflammation and associated redness, protect against sinus infections, clear mucus and phlegm, cure skin conditions like eczema and psoriasis, boost the immune system, fight fungal and viral infections, stimulate the mind and body, and protecting your home and body from a wide variety of germs.
Gelatin Capsules Sizes and shapes of Gelatin Capsules.
All About Zinc. Zinc is an essential element, necessary for sustaining all life. It is estimated that 3000 of the hundreds of thousands of proteins in the human body contain zinc. Signs of zinc deficiency includes hair loss, skin lesions, diarrhea, wasting of body tissues. Prolonged lack of zinc can result in death.
Master Index of Health-Related Articles on BSI.International