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Excerpts from: Study on Antibacterial Activity from Temu Lawak against Pathogenics Microbes Cell Destruction.

*Correspondence to: Elisa Friska Romasi
e-mail: elisa_friska@yahoo.com


(Special Edition)
Study on Antibacterial Activity from “Temu lawak” (Curcuma xanthorrhiza Roxb.) Rhizomes against Pathogenics Microbes Cell Destruction

Sylviana Husein, Adolf Parhusip and Elisa Friska Romasi
Food Technology Department, Universitas Pelita Harapan UPH Tower, Jalan. MH Thamrin
Boulevart 00-00, Lippo Karawaci, Tangerang 15811 Indonesia


Curcuma xanthorrhiza Roxb. is one type of herbs derived from family Zingiberaceae. Curcuma xanthorrhiza Roxb. rhizomes have been known to have antrimicrobial activity against some bacteria, such as Streptococcus mutans, Staphylococcus aureus and Salmonella.


Indonesia has various species of medicinal plants; one of them is Curcuma xanthorrhiza Roxb. (temu lawak). Traditionally, temu lawak has been used for food and medicinal purposes. Starch, atsiri oil, which contains curcuminoid are the main component of rhizome of Curcuma xanthorrhiza Roxb.

One of the atsiri oil components of temu lawak rhizome is xanthorrizol. Xanthorrizol can only be found in Curcuma xanthorrhiza Roxb. but not in other Curcuma. The xanthorizzol is known to have antibacterial, antiseptic, and antibiotic activities. Xanthorrizol inhibits the growth of Streptotococcus mutans.

Temu lawak rhizome contains curcumoid and oil atsiri, having biology activities. Generally, oil atsiri from temulawak rhizome contains xanthorrhizol, germakren, allo-aromadendren, tricyclin, and isofurogermakren. Curcumoid and xanthorrizol are the most active component and both are soluble in alcohol Alcohol extract contains alkaloids, tannins, phenolics, flavonoids, triterpenoid and glycoside. Antibacterial activity of ethanol extract against S.aureus might be come from terphenoid and curcurminoid. According to Dwidjoseputro (1994) in Ajizah et al. (2007), phenolic, flavonoid and alkaloid compound inhibit the synthesis of bacterial cell wall. The cell wall of bacteria is disrupted, resulting in weaken bacteria so that the ethanol extract could penetrate to the cell.

E. coli is a Gram negative bacterium that has lipoprotein, lipopolisaccharrida and porin at their outer membrane (Madigan et al., 2002). It also contains Ca2+ and Mg2+ that stabilize the outer membrane (Murray et al., 1998). The ethyl acetate extract contains polar and non polar compounds. Phytochemistry test (data not shown) shown that ethyl acetate extract contained alkaloid, tannin, phenolic, flavonoid, triterphenoid and glycoside.

Tannin compounds have the ability to chelate Ca2+ and Mg2+ ion in the outer membrane which causes stabilization disruption. The unstable outer membrane then is penetrated further by the extract. Lipopolysaccharide is a non polar compound that in the extract, can penetrate more than the polar com- pounds. The small molecules of polar compounds can penetrate through porin but larger polar com- pound can penetrate through cell wall after the che- lation process.

Temu lawak rhizome extract inhibits the growth of B.cereus and B.cereus spores. Even though the spore were more resistant than the vegetative cell, the extract inhibited the growth of spore. This result showed that extract of temu lawak rhizome had the ability to inhibit bacterial spore.

Alcohol extract is capable to inhibit the growth of protoplast of S.aureus and B.cereus more than their vegetative cell. Alcohol extract is also capable to inhibitE.coli.

The extract from temu lawak rhizome affects the morfologi of bacterial cell. Peptidoglycan in the cell wall constructs the shape of cell. The osmotic pressure inside cell is higher than outside. If there is no cell wall, the membrane cell can not stand on the cytoplasm and the cell will rupture (McKane & Kandel, 1996). The changes of bacterial shape showed that there were broken cell walls at the cell threated with extract. Cell wall is one of the target of the active compound of temulawak rhizome extract.

The data shown that the cell which have a cell wall were more resistant to the extract than the cell without a cell wall. This data also shown that temu lawak rhizome extract also had targets at the cell without cell wall. The target of the active component of extract might be cell membrane, nucleic acid or bacterial metabolism (McKane & Kandel, 1996).

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Articles about Temu Lawak Temulawak rhizome contains xanthorrhizol, germakren, allo-aromadendren, tricyclin, and isofurogermakren. Curcumoid and xanthorrizol are the most active component.

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It's not just about killing cancer....

But also about ending the causes of cancer
so it is no longer needed by the body.
The body expels disease when properly nourished.

Alternative web sites often are lost, are made illegal in the current political climate.

Because of the intrinsic value of this information for the reader, we at BSI, in addition to providing a link to the reference, also reprint it here for safe keeping. We kindly invite the author to contact us.

It appears obvious in many cancer-related publications, the author may be leery of liability. As such one must often read-between-the-lines, to understand what is revealed there. 

"Everything is backwards; everything is upside down. Doctors destroy health, lawyers destroy justice, universities destroy knowledge, governments destroy freedom, and the major media destroy information." ~ Michael Ellner

"Anti-dandruf shampoos cause dandruf and scalp disorders. Weight loss foods and drugs cause weight gain. Prescription drugs cause disease. Health insurance destroys health. Television and advertising kill individuality and inspiration." ~ I Wayan Nyepih




A few of the 60+ natural medicines we manufacture at BSI....

Traditional Bloodroot Salve
Compound A
Blood Root Jahe Yellow Powder
Compound B
Blood Root Jahe Magnesium
Yellow Salve

Compound BVC
Goldenseal Comfrey Aloe
Healing Salve

Compound C
Blood Root Jahe Salve
Compound D
Bromelain Papain Powder
Compound G
Jintan Hitam Beet Powder
Compound J
Cancer Killer
Compound K
Manggis Sirsap Powder
Compound L
Colloidal Minerals
Compound M
Noni Mint Powder
Compound NP
Poison Control
Compound S
Digestive Toner and Cleanse
Compound VL
Lung and Sinus Steamer Solution
Compound B Tincture
DMSO Vit C Bloodroot Bicarbonate Magnesium Iodine Jahe
Compound 1-5
Bone & Ligament Rebuilder
Compound O
Oral Parasite Medicine
Compound W
Lung & Sinus Tonic
Compound TL
Jamu BSI

Compound Z

Infusion Enhancement

Compound IZ
Nigella Sativa
Infusion Enhancement

Compound IN
Healing Eye Drops
Vitamin C - Silver - Magnesium - Electrolyte Healing for eyes

Compound ED
Tumor Direct Injection
Compound A-20
Vitamin C and Electrolytes Infusion
Compound IAA
Silver Hydrosol
Infusion Enhancement and Tumor Injection

Compound IS
Lemon Bath and Body Oil
Compound SO
Vita Bath
Healing Bath Salts

Compound V
Trace Elements Body Detox and Skin Purifier
Natural Insect Repellant
Bug Juice
Oral Healing Oils
Compound SOS
Trace Elements Face & Scalp Healing Conditioner
Oral Healing Kit
Oral Kit
Body Detox
and Healing Kit

Body Kit

Sorry, the medicines we make are sold only to our patients.